Lithium (Enzymatic) Assay (Liquid Stable)
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Product Features
Compared to existing methods, the new liquid stable Diazyme lithium assay provides improved reagent stability and a dramatically reduced cost per test. The assay features excellent accuracy and precision and offers an extended reportable range of 0.1-3.0 mmole/L lithium which will reduce the need for re-testing elevated patient samples. The method also demonstrates insignificant bias from indigenous ions and other interfering substances including hemoglobin, bilirubin, triglycerides and ascorbic acid. The assay can be applied to most common clinical chemistry analyzers, and application parameters are available from Diazyme.
Assay Principle
The Diazyme enzymatic Lithium assay is based on a lithium sensitive enzyme whose activity is lithium concentration dependent. The enzyme, a phosphatase, converts its substrate adenosine biphosphate (PAP) to hypoxanthine through a coupled enzymatic reactions to generate uric acid and hydrogen peroxide (H2O2). H2O2 generated is then quantified by a Trinder reaction.
Intended use
For the quantitative in vitro determination of lithium in serum samples. Serum levels of lithium are monitored when patients received therapeutic lithium for treatment of diseases such as bipolar disorder (manic depressive psychosis).
Product Catalog Number Packaging Method/Format
Kit (200 Tests) DZ116B-K R1: 2 x 20 mL
R2: 2 x 10 mL
 Enzymatic/Kinetic
Liquid stable
Calibrator DZ116B-Cal 3 x 3 mL  
Control DZ116B-Con 2 x 3 mL